Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide.
نویسندگان
چکیده
An artificial phosphopeptide recognized the difference between methylated and hydroxymethylated cytosines in DNA. The Sp1 zinc finger peptide substituted by phosphotyrosine effectively discriminated between 5-methylcytosine, 5-hydroxymethylcytosine ((hm)C) and unmethylated cytosine. The DNA recognition properties of the peptide differ from those of other chemicals that detect (hm)C.
منابع مشابه
Discrimination of methylcytosine from hydroxymethylcytosine in DNA molecules.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 29 شماره
صفحات -
تاریخ انتشار 2011